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The diagnostic evaluation of patients with this syndrome is complicatedIn arriving at a diagnosisit is important to exclude cases where the clinical presentation includes both serious medical illnesse.gpneumoniasystemic infectionetcand untreated or inadequately treated extrapyramidal signs and symptomsEPSOther important considerations in the differential diagnosis include central anticholinergic toxicityheat strokedrug feverand primary central nervous system pathology.

Patients should be counseled that dyslipidemia has occurred during treatment with ZyprexaPatients should have their lipid profile monitored regularlysee Warnings and Precautions5.5

The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increaseHoweverthe syndrome can developalthough much less commonlyafter relatively brief treatment periods at low doses or may even arise after discontinuation of treatment.

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